This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin
Human,Mouse,Dog(predicted: Rat,Pig,Cow,Horse,Rabbit,Sheep)
Flow-Cyt
Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.